NOX Inhibitors - A Promising Avenue for Ischemic Stroke

NOX Inhibitors - A Promising Avenue for Ischemic Stroke

NADPH-oxidase (NOX) mediated superoxide originally found on leukocytes, but now recognized in several types of cells in the brain. It has been shown to play an important role in the progression of stroke and related cerebrovascular disease. NOX is a multisubunit complex consisting of 2 membrane-associated and 4 cytosolic subunits. NOX activation occurs when cytosolic subunits translocate to the...

Epigenetic mechanisms in migraine: a promising avenue?

Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of hist...

a promising method of enhancement for early detection of ischemic stroke

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: computed tomography (ct) scan without contrast is the modality of choice for diagnosis of stroke. however, routine brain ct scan, with linear processing has some limitations in early diagnosis of ischemic stroke. the aim of this study was to evaluate and compare the sensitivity and specificity of processed ct i...

Angiopoietin-Like 4 and Ischemic Stroke: a Promising Start

Hemicraniectomy is a promising treatment in ischemic stroke.

The most devastating form of ischemic stroke is the large cerebral infarction. This type of infarction is commonly associated with cerebral edema which produces mass effect. If this mass effect is extensive enough, brain herniation and death can result. Hacke et al1 have coined the term ‘malignant’middle cerebral artery (MCA) territory infarction to describe the complete MCA territory infarctio...